ARTHRITIS INFORMATION
Risk Factors for the Development of Rheumatoid Arthritis
- Genetic predisposition: Certain inherited markers (especially HLA-DR variants) increase susceptibility and are linked to more aggressive disease progression.
- Smoking: One of the strongest modifiable risk factors. Smoking not only increases the likelihood of developing rheumatoid arthritis but is also associated with more severe disease and poorer treatment response.
- Age and sex: Rheumatoid arthritis most commonly develops in middle age and is more frequent in women, suggesting a hormonal influence on immune function.
- Chronic inflammation and autoimmunity: The presence of autoantibodies (such as rheumatoid factor and anti-CCP) before symptoms appear is associated with higher risk and more erosive disease.
- Obesity: Excess body weight contributes to systemic inflammation and may worsen disease activity and reduce responsiveness to therapy.
- Environmental exposures: Long-term exposure to pollutants, silica dust, or certain occupational irritants can increase risk by triggering immune dysregulation.
- Hormonal factors: Changes in estrogen levels (e.g., postpartum or menopause) may influence disease onset and flare patterns.
- Delayed diagnosis or treatment: Early, untreated inflammation accelerates joint damage, bone erosion, and loss of bone density.
- High disease activity over time: Persistent, uncontrolled inflammation drives ongoing joint destruction and systemic bone loss.
- Sedentary lifestyle: Lack of physical activity can contribute to reduced bone strength and worsen functional outcomes over time.
Arthritis Types and General Facts
There are more than 100 different types of arthrthis. The most common type of arthritis is osteoarthritis (OA) or degenerative joint disease. It is a common chronic, progressive musculoskeletal disorder characterized by gradual loss of articular cartilage. The disease most commonly affects the middle-aged and elderly, although it may begin earlier as a result of injury or overuse.
Rheumatoid arthritis is a chronic autoimmune disease that not only affects joints, but also significantly impacts bone health. Persistent inflammation drives the release of cytokines that stimulate osteoclast activity—the cells responsible for breaking down bone—while suppressing bone formation. Over time, this imbalance leads to reduced bone mineral density and progressive bone loss.
This results in both localized bone erosions at joints and a broader loss of bone mass. As bone architecture weakens, the skeleton becomes less stable contributing to ongoing pain and reduced function. This also makes you more prone to fractures
Osteoarthritis Pain Management and Non-Surgical Treatment Options
At present, there is no cure for OA. The goal of common non-surgical remedies, therapies and treatments are to collectively improve function and quality of life while limiting potential drug toxicity damage and complications. Non-surgical options include:
- Education (patient and spouse or family)
- Social support
- Physiotherapy (physical therapy)
- Occupational therapy
- Weight loss
- Exercise – The most important intervention in the management of OA. Exercise builds muscle strength and endurance, improves joint flexibility and motion.
- Arthritis Orthotics
- Laser Therapy
- Pulsed EMF (Electromagnetic field therapy)
- Ultrasound
- Transcutaneous electrical nerve stimulation (TENS)
- Acupuncture
- Diet and Nutrients
- Herbal remedies
- Vitamins/minerals
- Pharmacological therapy – Drugs that can be bought at pharmacies and drugstores without a prescription, like aspirin and ibuprofen.
- Lidocaine patch – A topical adhesive patch containing the local anesthetic lidocaine.
Surgical Treatment of Osteoarthritis
Surgical treatment of osteoarthritis is usually considered after a failure of non-surgical therapy options.
Total joint arthroplasty, the most surgically advanced in OA treatment, is the mainstay of surgical treatments. Other surgical procedures are: osteotomy, arthroscopy, arthrodesis and arthroplasty, and each has different indications and variable benefits.
PROVEN RELIEF FOR ARTHRITIS PAIN
Nonprescription “Stay-in-place” Lidocaine Patch with Menthol

